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Tailoring Cell Adhesion Using Surface‐Grafted Polymer Gradient Assemblies
Author(s) -
Bhat R. R.,
Chaney B. N.,
Rowley J.,
LiebmannVinson A.,
Genzer J.
Publication year - 2005
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200500858
Subject(s) - materials science , polymer , protein adsorption , grafting , adhesion , adsorption , chemical engineering , cell adhesion , surface modification , morphology (biology) , polymer chemistry , nanotechnology , biophysics , composite material , organic chemistry , chemistry , biology , engineering , genetics
Surface‐grafted polymer assemblies with a gradient in molecular weight (MW) and/or grafting density (σ) are used to tune protein adsorption, which consequently governs cell adhesion. Increasing the surface coverage of the polymer by increasing the MW and/or σ results in a decrease in the amount of protein adsorbed, which causes a decrease in the number of cells adhered and a change in cell morphology.