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Enzyme‐Mediated Degradation of Peptide‐Amphiphile Nanofiber Networks
Author(s) -
Jun H.W.,
Yuwono V.,
Paramonov S. E.,
Hartgerink J. D.
Publication year - 2005
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200500855
Subject(s) - nanofiber , peptide , amphiphile , materials science , nanostructure , degradation (telecommunications) , extracellular matrix , peptide sequence , cleavage (geology) , enzyme , biophysics , nanotechnology , biochemistry , copolymer , polymer , composite material , biology , computer science , telecommunications , fracture (geology) , gene
Peptide‐amphiphile nanofibers are prepared that incorporate a peptide sequence permitting enzyme‐mediated degradation (see Figure). Cleavage of the peptide sequence results in breakdown of the nanostructure and, consequently, the mechanical properties. This novel elastic nanofiber network is able to encapsulate dental pulp cells, supporting their proliferation and migration, and mimics several key properties of natural extracellular matrix.