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Single‐Walled Carbon Nanotube Spectroscopy in Live Cells: Towards Long‐Term Labels and Optical Sensors
Author(s) -
Heller D. A.,
Baik S.,
Eurell T. E.,
Strano M. S.
Publication year - 2005
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200500477
Subject(s) - carbon nanotube , photobleaching , raman spectroscopy , materials science , spectroscopy , nanotechnology , fluorescence , raman scattering , nanotube , optics , physics , quantum mechanics
Single‐walled carbon nanotubes form the basis of new non‐photobleaching cell markers that remain visible in live cells for up to three months and do not impede cell viability. In‐vitro spectroscopy of the intrinsic near‐IR fluorescence and Raman scattering of the nanotubes maps the localization of nanotube complexes, which accumulate in perinuclear endosomes (see Figure). The markers are also detectable in hematoxylin and eosin stained cells and exhibit spectral changes due to the nanotubes' environment.