Three‐Dimensional Microfluidic Tissue‐Engineering Scaffolds Using a Flexible Biodegradable Polymer | Zendy

Bettinger C. J. | Zendy; Weinberg E. J. | Zendy; Kulig K. M. | Zendy; Vacanti J. P. | Zendy; Wang Y. | Zendy; Borenstein J. T. | Zendy; Langer R. | Zendy

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Three‐Dimensional Microfluidic Tissue‐Engineering Scaffolds Using a Flexible Biodegradable Polymer

Author(s) -

Bettinger C. J.,

Weinberg E. J.,

Kulig K. M.,

Vacanti J. P.,

Wang Y.,

Borenstein J. T.,

Langer R.

Publication year - 2006

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.200500438

Subject(s) - microfluidics , materials science , microfabrication , biodegradable polymer , tissue engineering , polymer , nanotechnology , biomedical engineering , biocompatibility , composite material , fabrication , metallurgy , medicine , alternative medicine , pathology

Three‐dimensional microfluidic networks using a flexible biodegradable polymer have been fabricated using modified microfabrication processes tailored specifically for poly(glycerol‐ co ‐sebacate). A model hepatocyte cell line (HepG2) is seeded and perfused in the microfluidic networks to demonstrate cell viability and function, which is maintained in long‐term perfusion culture (see Figure; scale bar is 50 μm). The seeded, fully degradable device can potentially be integrated into a patient's existing vasculature in order to restore organ function.

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