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Three‐Dimensional Microfluidic Tissue‐Engineering Scaffolds Using a Flexible Biodegradable Polymer
Author(s) -
Bettinger C. J.,
Weinberg E. J.,
Kulig K. M.,
Vacanti J. P.,
Wang Y.,
Borenstein J. T.,
Langer R.
Publication year - 2006
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200500438
Subject(s) - microfluidics , materials science , microfabrication , biodegradable polymer , tissue engineering , polymer , nanotechnology , biomedical engineering , biocompatibility , composite material , fabrication , metallurgy , medicine , alternative medicine , pathology
Three‐dimensional microfluidic networks using a flexible biodegradable polymer have been fabricated using modified microfabrication processes tailored specifically for poly(glycerol‐ co ‐sebacate). A model hepatocyte cell line (HepG2) is seeded and perfused in the microfluidic networks to demonstrate cell viability and function, which is maintained in long‐term perfusion culture (see Figure; scale bar is 50 μm). The seeded, fully degradable device can potentially be integrated into a patient's existing vasculature in order to restore organ function.