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The Patterning and Alignment of Muscle Cells Using the Selective Adhesion of Poly(oligoethylene glycol methyl ether methacrylate)‐based ABA Block Copolymers
Author(s) -
Popescu D. C.,
Lems R.,
Rossi N. A. A.,
Yeoh C.T.,
Loos J.,
Holder S. J.,
Bouten C. V. C.,
Sommerdijk N. A. J. M.
Publication year - 2005
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200500039
Subject(s) - materials science , copolymer , adhesion , c2c12 , methacrylate , methyl methacrylate , myogenesis , ether , polymer chemistry , polymer , in vitro , composite material , organic chemistry , chemistry , biochemistry
The selective adhesion/delamination behavior of poly(oligoethylene glycol methyl ether methacrylate)‐based ABA block copolymers is exploited to generate patterned substrates consisting of alternating lanes of glass and copolymer‐coated gold. These patterns have been successfully used for the patterning and alignment of C2C12 muscle cells. The parallel‐oriented myotubes (see Figure) contract upon electrical stimulation, forming a promising 2D in‐vitro model for muscles.