Magnetite‐Loaded Polymeric Micelles as Ultrasensitive Magnetic‐Resonance Probes | Zendy

Ai H. | Zendy; Flask C. | Zendy; Weinberg B. | Zendy; Shuai X.T. | Zendy; Pagel M. D. | Zendy; Farrell D. | Zendy; Duerk J. | Zendy; Gao J. | Zendy

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Magnetite‐Loaded Polymeric Micelles as Ultrasensitive Magnetic‐Resonance Probes

Author(s) -

Ai H.,

Flask C.,

Weinberg B.,

Shuai X.T.,

Pagel M. D.,

Farrell D.,

Duerk J.,

Gao J.

Publication year - 2005

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.200401904

Subject(s) - micelle , materials science , ethylene glycol , magnetite , superparamagnetism , copolymer , biocompatible material , magnetic resonance imaging , peg ratio , nanoparticle , iron oxide , ethylene oxide , iron oxide nanoparticles , magnetite nanoparticles , nanotechnology , nuclear magnetic resonance , chemical engineering , magnetic nanoparticles , polymer , organic chemistry , chemistry , magnetic field , biomedical engineering , magnetization , aqueous solution , composite material , engineering , quantum mechanics , metallurgy , radiology , medicine , physics , finance , economics

Increased contrast in magnetic resonance imaging (MRI) is accomplished using polymeric micelles loaded with superparamagnetic iron oxide (SPIO) nanoparticles encapsulated in biocompatible, biodegradable poly(ϵ‐caprolactone)‐ b ‐poly(ethylene glycol) (PCL‐ b ‐PEG) copolymers (see Figure). The loaded micelles show significantly improved T 2 relaxivities and remarkable MRI detection sensitivity.

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