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Magnetite‐Loaded Polymeric Micelles as Ultrasensitive Magnetic‐Resonance Probes
Author(s) -
Ai H.,
Flask C.,
Weinberg B.,
Shuai X.T.,
Pagel M. D.,
Farrell D.,
Duerk J.,
Gao J.
Publication year - 2005
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200401904
Subject(s) - micelle , materials science , ethylene glycol , magnetite , superparamagnetism , copolymer , biocompatible material , magnetic resonance imaging , peg ratio , nanoparticle , iron oxide , ethylene oxide , iron oxide nanoparticles , magnetite nanoparticles , nanotechnology , nuclear magnetic resonance , chemical engineering , magnetic nanoparticles , polymer , organic chemistry , chemistry , magnetic field , biomedical engineering , magnetization , aqueous solution , composite material , engineering , quantum mechanics , metallurgy , radiology , medicine , physics , finance , economics
Increased contrast in magnetic resonance imaging (MRI) is accomplished using polymeric micelles loaded with superparamagnetic iron oxide (SPIO) nanoparticles encapsulated in biocompatible, biodegradable poly(ϵ‐caprolactone)‐ b ‐poly(ethylene glycol) (PCL‐ b ‐PEG) copolymers (see Figure). The loaded micelles show significantly improved T 2 relaxivities and remarkable MRI detection sensitivity.