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One‐Pot Reaction to Synthesize Biocompatible Magnetite Nanoparticles
Author(s) -
Li Z.,
Wei L.,
Gao M. Y.,
Lei H.
Publication year - 2005
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200401545
Subject(s) - biocompatible material , materials science , magnetite nanoparticles , magnetite , nanoparticle , nanotechnology , chemical engineering , magnetic nanoparticles , metallurgy , biomedical engineering , medicine , engineering
Biocompatible magnetite nanocrystals (see Figure) are prepared by thermal decomposition of ferric triacetylacetonate in 2‐pyrrolidone in the presence of monocarboxyl‐terminated poly(ethylene glycol) (MPEG‐COOH). The results reveal that MPEG is covalently bound to the nanocrystal surface by COOH groups. Magnetic resonance imaging (MRI) experiments indicate that the coated nanocrystals are potential MRI contrast agents due to their excellent water solubility and biocompatibility.