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Ferrocene‐Functionalized Cationic Polythiophene for the Label‐Free Electrochemical Detection of DNA
Author(s) -
Le Floch F.,
Ho H.A.,
HardingLepage P.,
Bédard M.,
NeaguPlesu R.,
Leclerc M.
Publication year - 2005
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200401474
Subject(s) - cationic polymerization , polythiophene , ferrocene , peptide nucleic acid , materials science , nucleic acid , dna , combinatorial chemistry , polymer , electrochemistry , conductive polymer , nanotechnology , polymer chemistry , electrode , chemistry , biochemistry , composite material
Specific, sensitive detection of unlabeled target DNA at room temperature is reported. A new, water‐soluble, ferrocene‐functionalized, cationic polythiophene is synthesized. This conducting polymer, used together with gold‐bound peptide nucleic acid (PNA) probes, makes, by a simple electrostatic method, DNA detection possible (see Figure).