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pH‐Triggered Thermally Responsive Polymer Core–Shell Nanoparticles for Drug Delivery
Author(s) -
Soppimath K. S.,
Tan D. C.W.,
Yang Y.Y.
Publication year - 2005
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200401057
Subject(s) - lower critical solution temperature , nanoparticle , materials science , polymer , drug delivery , nanotechnology , core (optical fiber) , chemical engineering , shell (structure) , molecule , drug carrier , organic chemistry , chemistry , copolymer , composite material , engineering
Novel polymer core–shell nanoparticles that exhibited a pH‐dependent lower critical solution temperature (LCST) have been synthesized. The nanoparticles displayed stable structure in a nominal physiological environment but deformed and precipitated in an acidic environment, thereby releasing the enclosed drug molecules (see Figure). The nanoparticles would make a promising carrier for targeting drugs to tumor tissues or cell interiors where the environment is characteristically acidic.

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