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Preparation of Fluorescent Silica Nanotubes and Their Application in Gene Delivery
Author(s) -
Chen C.C.,
Liu Y.C.,
Wu C.H.,
Yeh C.C.,
Su M.T.,
Wu Y.C.
Publication year - 2005
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200400966
Subject(s) - materials science , fluorescence , biomolecule , green fluorescent protein , nanotechnology , gene delivery , carbon nanotube , dna , nanotube , membrane , transfection , gene , biochemistry , chemistry , physics , quantum mechanics
Fluorescent silica nanotubes are synthesized through a sol–gel reaction using an anodic aluminum oxide membrane template. The nanotubes are filled with plasmid DNA encoding green fluorescence protein (GFP), which are incorporated into mammalian cells that subsequently express GFP (see Figure). The results demonstrate a novel application of nanotubes in biomolecule delivery.