Photopolymerization in Microfluidic Gradient Generators: Microscale Control of Substrate Compliance to Manipulate Cell Response | Zendy

Zaari N. | Zendy; Rajagopalan P. | Zendy; Kim S. K. | Zendy; Engler A. J. | Zendy; Wong J. Y. | Zendy

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Photopolymerization in Microfluidic Gradient Generators: Microscale Control of Substrate Compliance to Manipulate Cell Response

Author(s) -

Zaari N.,

Rajagopalan P.,

Kim S. K.,

Engler A. J.,

Wong J. Y.

Publication year - 2004

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.200400883

Subject(s) - microscale chemistry , microfluidics , photopolymer , materials science , self healing hydrogels , substrate (aquarium) , nanotechnology , mechanobiology , generator (circuit theory) , composite material , polymer , polymerization , power (physics) , polymer chemistry , oceanography , mathematics education , mathematics , geology , physics , quantum mechanics , biology , genetics

Integration of a microfluidic gradient generator and photopolymerization to fabricate novel hydrogels with tunable mechanical properties on the microscale (see Figure) is reported. This concept introduces a new class of materials that can be used to investigate the role of substrate elastic moduli in controlling cell morphology and cytoskeletal organization, and more generally, cell behavior.

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