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Bicontinuous, Thermoresponsive, L 3 ‐Phase Silica Nanocomposites and Their Smart Drug‐Delivery Applications
Author(s) -
Chang J. H.,
Shim C. H.,
Kim B. J.,
Shin Y.,
Exarhos G. J.,
Kim K. J.
Publication year - 2005
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200400545
Subject(s) - materials science , nanocomposite , drug delivery , nanoscopic scale , phase (matter) , chemical engineering , polymer , smart polymer , nanotechnology , polymer chemistry , composite material , organic chemistry , chemistry , engineering
Bicontinuous, thermosensitive, L 3 ‐phase silica nanocomposites are prepared by self‐assembly of silicified L 3 ‐phase silicates and L 3 ‐phase silicates integrated with thermoresponsive poly( N ‐isopropylacryl amide) (PNIPAm; see Figure). In the L 3 ‐PNIPAm material, interpenetrating nanoscale networks of silica and polymer gel are formed, with which highly controlled drug delivery is successfully demonstrated.