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Fabrication of Protein/Silica Core–Shell Nanoparticles by Microemulsion‐Based Molecular Wrapping
Author(s) -
Ma D.,
Li M.,
Patil A. J.,
Mann S.
Publication year - 2004
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200400351
Subject(s) - microemulsion , myoglobin , materials science , nanoparticle , fabrication , molecule , nanotechnology , hydrolysis , chemical engineering , condensation , organic chemistry , pulmonary surfactant , chemistry , medicine , alternative medicine , physics , pathology , engineering , thermodynamics
A novel process for wrapping individual myoglobin molecules with an ultrathin shell of silica is reported. Confinement of single protein molecules in microemulsion water droplets followed by the controlled hydrolysis and condensation of tetramethoxysilane at the oil/water interface produces discrete protein/ silica nanoparticles (see Figure) without loss of myoglobin structure and function.