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Controlling Degradation of Hydrogels via the Size of Crosslinked Junctions
Author(s) -
Kong H. J.,
Alsberg E.,
Kaigler D.,
Lee K. Y.,
Mooney D. J.
Publication year - 2004
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200400014
Subject(s) - library science , computer science
The degradation rates of hydrogels are shown to be regulated by the modulation of the dissociation rates of the polymer chains via a size mismatch in the crosslinking zones. This method (used to control degradation) can be exploited in order to engineer cartilage tissue in vivo (see Figure).