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Control of Monocyte Morphology on and Response to Model Surfaces for Implants Equipped with Anti‐Inflammatory Agent
Author(s) -
BenkiraneJessel N.,
Lavalle P.,
Meyer F.,
Audouin F.,
Frisch B.,
Schaaf P.,
Ogier J.,
Decher G.,
Voegel J.C.
Publication year - 2004
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200306613
Subject(s) - materials science , inflammation , inflammatory response , monocyte , secretion , polyelectrolyte , nanotechnology , biomedical engineering , morphology (biology) , biophysics , composite material , immunology , polymer , medicine , biology , genetics
In order to prevent local chronic inflammation due to biomaterials such as implants , surface coatings that are able to modulate inflammatory response have been developed. It is shown that polyelectrolyte multilayers containing alpha‐melanocyte‐stimulating hormone (α‐MSH) can be advantageously used for this purpose. The presence of α‐MSH has been demonstrated to induce cellular responses that can be modulated by varying the film architecture (see Figure).