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Self‐Assembling Polymer–Peptide Conjugates: Nanostructural Tailoring
Author(s) -
Collier J. H.,
Messersmith P. B.
Publication year - 2004
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200306379
Subject(s) - peptide , materials science , polymer , copolymer , ethylene glycol , conjugated system , fibril , self assembly , beta sheet , conjugate , nanotechnology , polymer chemistry , polymer science , chemical engineering , biophysics , chemistry , composite material , biochemistry , mathematical analysis , mathematics , engineering , biology
The synthesis and solution behavior of a series of β‐sheet fibril‐forming peptide–polymers is described. Several block copolymer architectures are explored, with various lengths and arrangements of the peptide and polymer blocks. One peptide–polymer, an 11‐amino acid peptide conjugated to a polydisperse poly(ethylene glycol) chain, has the ability to form uncommonly regular, aligned, and minimally aggregated β‐sheet fibrils (see Figure).