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Chemically Modified Calcium Phosphates as Novel Materials for Bisphosphonate Delivery
Author(s) -
Josse S.,
Faucheux C.,
Soueidan A.,
Grimandi G.,
Massiot D.,
Alonso B.,
Janvier P.,
Laïb S.,
Gauthier O.,
Daculsi G.,
Guicheux J.,
Bujoli B.,
Bouler J.M.
Publication year - 2004
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200306340
Subject(s) - bisphosphonate , bone resorption , resorption , materials science , calcium , dentin , diphosphonates , dentistry , osteoporosis , medicine , metallurgy , composite material
A potent inhibitor for bone resorption , the gem‐bisphosphonate zoledronate, has been chemically associated with calcium‐deficient apatites. The ability of such materials to release the zoledronate, resulting in the inhibition of osteoclastic resorption, is demonstrated using a specific in‐vitro bone resorption model. The resorption activity is typically characterized by the formation of lacunae on the surface of dentin slices (see Figure).