Chemically Modified Calcium Phosphates as Novel Materials for Bisphosphonate Delivery | Zendy

Josse S. | Zendy; Faucheux C. | Zendy; Soueidan A. | Zendy; Grimandi G. | Zendy; Massiot D. | Zendy; Alonso B. | Zendy; Janvier P. | Zendy; Laïb S. | Zendy; Gauthier O. | Zendy; Daculsi G. | Zendy; Guicheux J. | Zendy; Bujoli B. | Zendy; Bouler J.M. | Zendy

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Chemically Modified Calcium Phosphates as Novel Materials for Bisphosphonate Delivery

Author(s) -

Josse S.,

Faucheux C.,

Soueidan A.,

Grimandi G.,

Massiot D.,

Alonso B.,

Janvier P.,

Laïb S.,

Gauthier O.,

Daculsi G.,

Guicheux J.,

Bujoli B.,

Bouler J.M.

Publication year - 2004

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.200306340

Subject(s) - bisphosphonate , bone resorption , resorption , materials science , calcium , dentin , diphosphonates , dentistry , osteoporosis , medicine , metallurgy , composite material

A potent inhibitor for bone resorption , the gem‐bisphosphonate zoledronate, has been chemically associated with calcium‐deficient apatites. The ability of such materials to release the zoledronate, resulting in the inhibition of osteoclastic resorption, is demonstrated using a specific in‐vitro bone resorption model. The resorption activity is typically characterized by the formation of lacunae on the surface of dentin slices (see Figure).

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