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Intracellular Delivery of Quantum Dots for Live Cell Labeling and Organelle Tracking
Author(s) -
Derfus A. M.,
Chan W. C. W.,
Bhatia S. N.
Publication year - 2004
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200306111
Subject(s) - quantum dot , organelle , intracellular , mitochondrion , nanotechnology , tracking (education) , materials science , nucleus , subcellular localization , cell , semiconductor , gene delivery , biophysics , microbiology and biotechnology , cytoplasm , gene , biology , optoelectronics , biochemistry , transfection , psychology , pedagogy
Several strategies borrowed from the field of gene delivery are adapted to enhance delivery of semiconductor quantum dots (QDs) to the interior of live cells. To traffic QDs to subcellular organelles, QDs were then derivatized with known peptide localization sequences, demonstrating the ability to target QDs to the nucleus and mitochondria (see Figure).