Premium
“Non‐Fouling” Oligo(ethylene glycol)‐ Functionalized Polymer Brushes Synthesized by Surface‐Initiated Atom Transfer Radical Polymerization
Author(s) -
Ma H.,
Hyun J.,
Stiller P.,
Chilkoti A.
Publication year - 2004
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200305830
Subject(s) - atom transfer radical polymerization , ethylene glycol , materials science , polymer , monolayer , polymer chemistry , polymerization , microscale chemistry , chemical engineering , radical polymerization , adsorption , protein adsorption , polymer brush , nanotechnology , organic chemistry , chemistry , composite material , mathematics education , mathematics , engineering
The in‐situ synthesis of oligo(ethylene glycol)‐functionalized polymer brushes from a self‐assembled monolayer of an alkanethiol on gold that presents a tethered initiator by surface‐initiated atom transfer radical polymerization is reported. These polymer brushes exhibit no detectable adsorption of proteins, and are cell‐resistant for up to a month under typical cell culture conditions. The synthesis method is compatible with a range of patterning techniques from the nano‐ to the microscale, and enables the patterning of cells in a biologically relevant milieu over extended periods of time. Images of the brushes are shown on the inside front cover.