Size‐Controlled Formation of a Calcium Phosphate‐Based Organic–Inorganic Hybrid Vector for Gene Delivery Using Poly(ethylene glycol)‐  block  ‐poly(aspartic acid) | Zendy

Kakizawa Y. | Zendy; Miyata K. | Zendy; Furukawa S. | Zendy; Kataoka K. | Zendy

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Size‐Controlled Formation of a Calcium Phosphate‐Based Organic–Inorganic Hybrid Vector for Gene Delivery Using Poly(ethylene glycol)‐ block ‐poly(aspartic acid)

Author(s) -

Kakizawa Y.,

Miyata K.,

Furukawa S.,

Kataoka K.

Publication year - 2004

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.200305782

Subject(s) - ethylene glycol , materials science , nuclease , copolymer , calcium , gene delivery , peg ratio , phosphate , aspartic acid , chemical engineering , dna , polymer chemistry , polymer , transfection , gene , biochemistry , chemistry , amino acid , finance , economics , engineering , metallurgy , composite material

Poly(ethylene glycol) (PEG)‐covered hybrid particles (see Figure) of calcium phosphate (CaP), and plasmid DNA (pDNA) have been prepared in a size‐controllable manner in the presence of a block copolymer. The particles show a substantial colloidal stability as well as tolerance of entrapped pDNA against nuclease attack in the medium, and achieve a significantly higher gene expression compared to conventional precipitates.

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