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Direct Patterning of Protein‐ and Cell‐Resistant Polymeric Monolayers and Microstructures
Author(s) -
Khademhosseini A.,
Jon S.,
Suh K.Y.,
Tran T.N.T.,
Eng G.,
Yeh J.,
Seong J.,
Langer R.
Publication year - 2003
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200305433
Subject(s) - materials science , monolayer , fabrication , ethylene glycol , microstructure , copolymer , nanotechnology , polymer , chemical engineering , composite material , medicine , alternative medicine , pathology , engineering
A simple technique is introduced to pattern proteins and cells with precise control over the feature topography (see Figure, white bar indicates 20 μm). The technique uses a combination of a molding process and a novel poly(ethylene glycol) copolymer to form topographical features ranging from polymeric monolayers to microstructures via simple modifications to the fabrication process.