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Alignment of Long DNA Molecules on Templates Generated via Dip‐Pen Nanolithography
Author(s) -
Nyamjav D.,
Ivanisevic A.
Publication year - 2003
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200305342
Subject(s) - combing , nanolithography , template , dip pen nanolithography , materials science , molecule , nanotechnology , polymer , allylamine , dna , polyelectrolyte , fabrication , chemistry , composite material , organic chemistry , medicine , biochemistry , alternative medicine , pathology
A methodology to place and stretch long DNA molecules by coupling dip‐pen Nanolithography with molecular combing is presented. Templates were fabricated on SiO x surfaces using a positively charged polymer, poly(allylamine hydrochloride). Upon molecular combing, DNA molecules elongate on the surface (for example, see Figure) and are localized by the presence of the charged lithographically defined structures.