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Bioactive Coatings Based on a Polyelectrolyte Multilayer Architecture Functionalized by Embedded Proteins
Author(s) -
Jessel N.,
Atalar F.,
Lavalle P.,
Mutterer J.,
Decher G.,
Schaaf P.,
Voegel J.C.,
Ogier J.
Publication year - 2003
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.200304634
Subject(s) - polyelectrolyte , lysine , materials science , biomaterial , surface modification , nanotechnology , protein adsorption , layer (electronics) , biophysics , chemical engineering , amino acid , biochemistry , polymer , chemistry , biology , engineering , composite material
Does a signal protein imbedded in a polyelectrolyte layer keep its activity? The study reported here demonstrates that cells can indeed interact with proteins incorporated in poly( L ‐lysine/glutamic acid) multilayer films. In contrast, poly( D ‐lysine) acts as a barrier to cell communication. For the case of monocytic cells the mechanism of contact with the active protein is elucidated. It is believed that such functionalized coatings could be useful tools for the modification of biomaterial surfaces with applications in, e.g., implants or tissue engineering.