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Engineering macromolecules self‐assembly: Molecular tubes vs. protein sheets via single amino acid substitutions in E. coli glutamine synthetase
Author(s) -
Dabrowski Michael J.,
Atkins William M.
Publication year - 1995
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.19950071209
Subject(s) - supramolecular chemistry , yield (engineering) , macromolecule , materials science , glutamine synthetase , self assembly , glutamine , molecule , amino acid , nanotechnology , protein engineering , biochemistry , enzyme , biology , chemistry , organic chemistry , composite material
Protein engineering provides a rationale for obtaining self‐assembling molecules which yield supramolecular arrays with varying quanternary architectures. An example is E. coli glutamine synthetase which can be manipulated to yield molecular tubes (see figure), cables, and hexagonally packed sheets.