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One‐step preparation of double‐walled microspheres
Author(s) -
Pekarek Kathleen J.,
Jacob Jules S.,
Mathiowitz Edith
Publication year - 1994
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.19940060916
Subject(s) - microsphere , materials science , polymer , characterization (materials science) , nanotechnology , core (optical fiber) , evaporation , drug delivery , chemical engineering , composite material , physics , engineering , thermodynamics
Multilayered microspheres for drug delivery can be produced by several methods, but most techniques involve several stages and often lead to layers of non‐uniform thickness. The solcent evaporation method of producing double‐layered microspheres described here svoids these difficulties, a single step yielding micrespheres consisting of an inner core of polymer surrounded by a second polymer. The theory is presented and the characterization of the microspheres discussed.