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Highly effective surfactants with low hemolytic activity
Author(s) -
Riess Jean G.,
Pace Simonne,
Zarif Leila
Publication year - 1991
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.19910030507
Subject(s) - hemolysis , materials science , hydrocarbon , surface modification , chemical engineering , nanotechnology , biophysics , organic chemistry , chemistry , biology , engineering , immunology
Communication: Fluorochemicals show potential as highly surface‐active but non‐hemolyzing surfactants , an important combination of properties for biomedical applications such as blood substitutes and contrast agents. Hydrocarbon‐based surfactants suffer from the disadvantage that as the length of the hydrocarbon chain (and therefore surface activity) increases, cell‐destruction (hemolysis) also increases. The fluorinated srufactants, however, exhibit the opposite effect, an increase in chain length and surface activity leading to reduced hemolysis.