Open AccessFlow Injection Analysis with Tubular Membrane Ion‐Selective Electrode and Coated Wires for Buspirone Hydrochloride
Author(s) -
AbdelGhani Nour,
Issa Yousry,
Shoukry Adel,
Ahmed Howayda
Publication year - 2007
Publication title -
annali di chimica
Language(s) - English
Resource type - Journals
eISSN - 1612-8877
pISSN - 0003-4592
DOI - 10.1002/adic.200690090
Subject(s) - potentiometric titration , electrode , ion selective electrode , chemistry , tetraphenylborate , analytical chemistry (journal) , reference electrode , quinhydrone electrode , membrane , sodium tetraphenylborate , flow injection analysis , inorganic chemistry , selectivity , ion , chromatography , detection limit , electrolyte , organic chemistry , biochemistry , catalysis
New Plastic membrane ion‐selective electrode for buspirone hydrochloride based on buspironium tetraphenylborate was prepared. The electrode exhibited mean slope of calibration graph of 58.4 mV per decade of BusCl concentration at 25 °C. The electrode can be used within the concentration range 6.3 × 10 ‐5 ‐10 ‐2 M BusCl at a pH range of 2.5‐7.0. The standard electrode potentials were determined at different temperatures and used to calculate the isothermal temperature coefficient of the electrode, amounting to 0.00056 V °C ‐1 . The electrode showed a very good selectivity for BusCl with respect to a number of inorganic cations, sugars and amino acids. The electrode was applied to the potentiometric determination of the buspirone ion and its pharmaceutical preparation under batch and flow injection conditions. Also, buspirone was determined by conductimetric titrations. Graphite rod, copper and silver coated wire electrodes were prepared and characterized as sensors for the drug under investigation.