Premium
Microfluidized Dextran Microgels Loaded with Cisplatin/SPION Lipid Nanotherapeutics for Local Colon Cancer Treatment via Oral Administration (Adv. Healthcare Mater. 20/2022)
Author(s) -
Lu I.Lin,
Yu TingWei,
Liu TeI,
Chen HsinHung,
Yang YingChieh,
Lo ChunLiang,
Wang ChiYa,
Chiu HsinCheng
Publication year - 2022
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202270120
Subject(s) - dextran , cancer , colorectal cancer , nanomedicine , cancer research , cisplatin , cancer cell , materials science , nanoparticle , nanotechnology , chemistry , medicine , chemotherapy , biochemistry
Nanomedicines In article 2201140 by Hsin‐Cheng Chiu and co‐workers, an oral polysaccharide microgel formulation containing dual‐modality therapeutic nanoparticles developed for local treatment of colon cancer is imparted to hierarchical targeting residues, leading to increases in colon retention and cancer cell uptake of nanotherapeutics. With enzymatic degradation of dextran microgels occurring exclusively in the colon, the nanotherapeutics internalized by colon cancer cells exhibit sound anticancer effects.