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Multifunctional Nanofibrous Scaffolds with Angle‐Ply Microstructure and Co‐Delivery Capacity Promote Partial Repair and Total Replacement of Intervertebral Disc (Adv. Healthcare Mater. 19/2022)
Author(s) -
Han Feng,
Yu Qifan,
Chu Genglei,
Li Jiaying,
Zhu Zhuang,
Tu Zhengdong,
Liu Changjiang,
Zhang Weidong,
Zhao Runze,
Mao Haijiao,
Han Fengxuan,
Li Bin
Publication year - 2022
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202270116
Subject(s) - intervertebral disc , materials science , microstructure , biomedical engineering , medicine , composite material , surgery
Biomimetic Structures Annulus fibrosus (AF) repair is critical for treating disc herniation. In article 2200895, Fengxuan Han, Bin Li, and co‐workers fabricate aligned core–shell nanofibrous scaffolds mimicking AF microstructure and realize temporal release of drugs for AF repair. Fast release of ibuprofen‐ameliorated inflammation and sustained release of TGF β 3 promote cell proliferation and ECM secretion.