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Red Light‐Responsive Upconverting Nanoparticles for Quantitative and Controlled Release of a Coumarin‐Based Prodrug
Author(s) -
Brion Anaïs,
Chaud Juliane,
Léonard Jérémie,
Bolze Frédéric,
Chassaing Stefan,
Frisch Benoît,
Heurtault Béatrice,
Kichler Antoine,
Specht Alexandre
Publication year - 2023
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202201474
Subject(s) - prodrug , nanoparticle , nanomedicine , conjugated system , materials science , photon upconversion , nanotechnology , nanocapsules , nanocarriers , chemistry , combinatorial chemistry , luminescence , organic chemistry , optoelectronics , polymer , biochemistry
Photolytic reactions allow the optical control of the liberation of biological effectors by photolabile protecting groups. The development of versatile technologies enabling the use of deep‐red or NIR light excitation still represents a challenging issue, in particular for light‐induced drug release (e.g., light‐induced prodrug activation). Here, light‐sensitive biocompatible lipid nanocapsules able to liberate an antitumoral drug through photolysis are presented. It is demonstrated that original photon upconverting nanoparticles (LNC‐UCs) chemically conjugated to a coumarin‐based photocleavable linker can quantitatively and efficiently release a drug by upconversion luminescence‐assisted photolysis using a deep‐red excitation wavelength. In addition, it is also able to demonstrate that such nanoparticles are stable in the dark, without any drug leakage in the absence of light. These findings open new avenues to specifically liberate diverse drugs using deep‐red or NIR excitations for future therapeutic applications in nanomedicine.