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Sulfated Alginate Hydrogels Prolong the Therapeutic Potential of MSC Spheroids by Sequestering the Secretome (Adv. Healthcare Mater. 21/2021)
Author(s) -
GionetGonzales Marissa,
Casella Alena,
Diloretto Daphne,
Ginnell Clara,
Griffin Katherine H.,
Bigot Anne,
Leach J. Kent
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202170104
Subject(s) - mesenchymal stem cell , stromal cell , spheroid , microbiology and biotechnology , self healing hydrogels , in vitro , sulfation , secretion , chemistry , cancer research , biology , biochemistry , organic chemistry
Mesenchymal Stromal Cells In article number 2101048 by J. Kent Leach and co‐workers, spheroids of mesenchymal stromal cells (MSCs) secrete high levels of relevant growth factors (GFs) for tissue regeneration. Sulfated alginate can sequester these GFs through ionic interactions, allowing increased therapeutic potency to invading cells. This paper investigates how MSC spheroidsecreted GFs are retained in sulfated alginate and their ability to influence cell function in vitro.