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A Biomimetic In Vitro Model of the Kidney Filtration Barrier Using Tissue‐Derived Glomerular Basement Membrane (Adv. Healthcare Mater. 16/2021)
Author(s) -
Wang Dan,
Sant Snehal,
Ferrell Nicholas
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202170073
Subject(s) - basement membrane , membrane , glomerular basement membrane , filtration (mathematics) , in vitro , in vivo , permeability (electromagnetism) , kidney , biophysics , materials science , chemistry , microbiology and biotechnology , medicine , biology , biochemistry , glomerulonephritis , statistics , mathematics
Glomerular Basement Membranes In article number 2002275 by Nicholas Ferrell and co‐workers, a biomimetic tissue culture model of the kidney filtration barrier is developed to evaluate molecular transport. The in vitro filtration barrier model employs kidney‐derived glomerular basement membrane to replicate the in vivo microenvironment. The filtration barrier model exhibits molecular selectivity and damage to the basement membrane increases molecular permeability.