Premium
Soluble and Microparticle‐Based Delivery of TLR4 and TLR9 Agonists Differentially Modulate 3D Chemotaxis of Bone Marrow‐Derived Dendritic Cells (Adv. Healthcare Mater. 15/2021)
Author(s) -
Atalis Alexandra,
Dixon J. Brandon,
Roy Krishnendu
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202170068
Subject(s) - chemokine , chemotaxis , immune system , lymphatic system , dendritic cell , tlr9 , microbiology and biotechnology , adjuvant , lymphatic endothelium , immunology , biology , medicine , receptor , biochemistry , gene expression , dna methylation , gene
Dendritic Cells Migration of dendritic cells (DCs) from peripheral tissues to the draining lymph‐node is critical for our immune responses to vaccines and against various pathogens. In article 2001899, Alexandra Atalis, J. Brandon Dixon, and Krishnendu Roy develop a method using a microfluidic device and related statistical analyses tools to study DC migration in 3D in response to vaccine adjuvants and lymphatic chemokines. The work shows how DCs differentially respond to soluble versus particulate carriers of adjuvants and to various adjuvant types. The cover image is an artistic view depicting the interface of engineering and biology to model and study the fundamental mechanisms of immune cell migration to lymphatics from peripheral tissues. Cover art by: Victoria Lozano Escarra, Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA.