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Neuroinflammation: Design and Evaluation of an In Vitro Mild Traumatic Brain Injury Modeling System Using 3D Printed Mini Impact Device on the 3D Cultured Human iPSC Derived Neural Progenitor Cells (Adv. Healthcare Mater. 12/2021)
Author(s) -
Shi Wen,
Dong Pengfei,
Kuss Mitchell A.,
Gu Linxia,
Kievit Forrest,
Kim Hyung Joon,
Duan Bin
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202170059
Subject(s) - neuroinflammation , neurosphere , microglia , traumatic brain injury , in vitro , neural stem cell , astrocyte , progenitor cell , medicine , neuroscience , biomedical engineering , materials science , microbiology and biotechnology , chemistry , central nervous system , stem cell , psychology , immunology , biology , inflammation , endothelial stem cell , biochemistry , psychiatry , adult stem cell
In article number 2100180 by Bin Duan and co‐workers, a mini weight drop impact device is 3D printed, which can produce controlled and repeated impact injury to 3D cultured human iPSC derived neurospheres. This in vitro platform shows that both increased amount of impact injury and the existence of microglia enhance the astrocyte activation, which recapitulates several hallmarks of mild traumatic brain injury.