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Translational Nanomedicine: Translational Nanotherapeutics Reprograms Immune Microenvironment in Malignant Pleural Effusion of Lung Adenocarcinoma (Adv. Healthcare Mater. 12/2021)
Author(s) -
Song Zhenhuan,
Luo Weizhan,
Zheng Haichong,
Zeng Yunxiang,
Wang Jinlin,
Chen Tianfeng
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202170055
Subject(s) - immune system , nanomedicine , cancer research , medicine , pleural effusion , malignant pleural effusion , lung , translational research , tumor microenvironment , immunology , materials science , pathology , nanotechnology , nanoparticle
In article number 2100149 by Tianfeng Chen, Jinlin Wang, and co‐workers, a new Se nanoparticle (SeNP)‐based translation of lung cancer‐related malignant pleural effusion (MPE) nanotherapeutic strategy is operated by transforming “cold” MPE to “hot” MPE. This translational nanotherapeutics can not only regulate effectively the functions and activities of various immune cells in MPE, mediating an immunosuppressive status, but also increase the production of metabolites associated with tumor growth inhibition and immune response activation.