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Enhanced Apoptosis: TRAIL‐Armed ER Nanosomes Induce Drastically Enhanced Apoptosis in Resistant Tumor in Combination with the Antagonist of IAPs (AZD5582) (Adv. Healthcare Mater. 11/2021)
Author(s) -
Hou Huan,
Su Kui,
Huang Chaohong,
Yuan Qian,
Li Shuyi,
Sun Jianwu,
Lin Yue,
Du Zhiyun,
Ke Changhong,
Yuan Zhengqiang
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202170052
Subject(s) - apoptosis , in vivo , antagonist , cancer research , tumor necrosis factor alpha , endoplasmic reticulum , tropism , chemistry , inhibitor of apoptosis , microbiology and biotechnology , programmed cell death , medicine , biology , immunology , receptor , biochemistry , virus
The antitumor effect of TNF‐related apoptosis‐inducing ligand (TRAIL)‐loaded cellular endoplasmic reticulum derived nanosomes (ERN‐Ts) is investigated in article number 2100030 by Zhengqiang Yuan, Changhong Ke, and co‐workers, in a mouse xenograft tumor model. ERN‐T has good tumor tropism and with its combined therapy with AZD5582, the antagonist of inhibitors of apoptosis proteins induces strikingly enhanced apoptosis in resistant tumors and thus significantly suppresses tumor growth in vivo.