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Microvasculatures: Multiphoton‐Guided Creation of Complex Organ‐Specific Microvasculature (Adv. Healthcare Mater. 10/2021)
Author(s) -
Rayner Samuel G.,
Howard Caitlin C.,
Mandrycky Christian J.,
Stamenkovic Stefan,
Himmelfarb Jonathan,
Shih Andy Y.,
Zheng Ying
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202170048
Subject(s) - regenerative medicine , multicellular organism , angiogenesis , multiphoton fluorescence microscope , tissue engineering , in vivo , biomedical engineering , extracellular matrix , microbiology and biotechnology , medicine , chemistry , biology , stem cell , cancer research , fluorescence microscope , cell , biochemistry , physics , fluorescence , quantum mechanics
Engineering functional tissues for regenerative medicine and human disease modeling is limited by difficulty re‐creating in vivo‐like microvasculatures. In article number 2100031, Ying Zheng and co‐workers report the successful combination of multiphoton microscopy with directed angiogenesis to precisely generate perfusable 3D organ‐specific capillary beds within natural extracellular matrices. These methods enable full cellularization of complex capillary models and the creation of multicellular, heterogeneous, and hierarchical vasculatures.