Premium
Fiber Networks: The Plasticity of Nanofibrous Matrix Regulates Fibroblast Activation in Fibrosis (Adv. Healthcare Mater. 8/2021)
Author(s) -
Jia Yuanbo,
Wang Yanzhong,
Niu Lele,
Zhang Hang,
Tian Jin,
Gao Dengfeng,
Zhang Xiaohui,
Lu Tian Jian,
Qian Jin,
Huang Guoyou,
Xu Feng
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202170039
Subject(s) - plasticity , fibroblast , microscale chemistry , matrix (chemical analysis) , cytoskeleton , microbiology and biotechnology , extracellular matrix , materials science , fibrosis , fiber , chemistry , biology , medicine , composite material , cell culture , psychology , pathology , cell , biochemistry , genetics , mathematics education
Little attention has been paid to the effect of matrix fiber‐network plasticity at the microscale. In article number 2001856, Jin Qian, Guoyou Huang, Feng Xu, and co‐workers find a significant decrease in plasticity of native fibrotic tissues, which is associated with increased matrix crosslinking. They demonstrate that the decrease of matrix plasticity promotes fibroblast activation and spreading using a plasticity‐controlled 3D culture system, which is mediated through cytoskeletal tension and nuclear translocation of Yes‐associated protein.