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Cartilage Regeneration: Encapsulated Mesenchymal Stromal Cell Microbeads Promote Endogenous Regeneration of Osteoarthritic Cartilage Ex Vivo (Adv. Healthcare Mater. 8/2021)
Author(s) -
Sahu Neety,
Agarwal Pranay,
Grandi Fiorella,
Bruschi Michela,
Goodman Stuart,
Amanatullah Derek,
Bhutani Nidhi
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202170038
Subject(s) - mesenchymal stem cell , cartilage , regeneration (biology) , ex vivo , paracrine signalling , microbiology and biotechnology , stromal cell , self healing hydrogels , in vivo , chemistry , medicine , cancer research , biology , anatomy , biochemistry , receptor , organic chemistry
In article number 2002118, Nidhi Bhutani and co‐workers employ microencapsulation of mesenchymal stromal cells (MSCs) in alginate hydrogels to sequester MSCs and study their specific paracrine effects in response to patient‐derived osteoarthritic (OA) cartilage. The secretome of microencapsulated MSCs, primed to OA cartilage, is able to promote endogenous regeneration in OA cartilage ex vivo by orchestrating a proliferative and anti‐apoptotic microenvironment.