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Spinal Cord Injury Repair: NSCs Migration Promoted and Drug Delivered Exosomes‐Collagen Scaffold via a Bio‐Specific Peptide for One‐Step Spinal Cord Injury Repair (Adv. Healthcare Mater. 8/2021)
Author(s) -
Zhang Lulu,
Fan Caixia,
Hao Wangping,
Zhuang Yan,
Liu Xiru,
Zhao Yannan,
Chen Bing,
Xiao Zhifeng,
Chen Yanyan,
Dai Jianwu
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202170034
Subject(s) - spinal cord injury , scaffold , mesenchymal stem cell , spinal cord , paclitaxel , medicine , neural stem cell , exosome , microvesicles , microbiology and biotechnology , stem cell , biomedical engineering , surgery , chemistry , pathology , chemotherapy , biology , microrna , biochemistry , psychiatry , gene
To achieve one‐step spinal cord injury (SCI) repairs, in article number 2001896 and Yanyan Chen, Jianwu Dai, and co‐workers, a scaffold‐retained paclitaxel‐loaded exosome from mesenchymal stem cells (MExos) is established. Benefiting from the synergistic effects of endogenous NSCs recruitment and NSCs differentiation into neurons induced by MExos and paclitaxel respectively in the injured site, this multifunctional scaffold shows a superior performance for motor functional recovery after complete SCI in rats.