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Cartilage Substitutes: Graphene Oxide‐Doped Gellan Gum–PEGDA Bilayered Hydrogel Mimicking the Mechanical and Lubrication Properties of Articular Cartilage (Adv. Healthcare Mater. 7/2021)
Author(s) -
Trucco Diego,
Vannozzi Lorenzo,
Teblum Eti,
Telkhozhayeva Madina,
Nessim Gilbert Daniel,
Affatato Saverio,
AlHaddad Hind,
Lisignoli Gina,
Ricotti Leonardo
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202170029
Subject(s) - materials science , gellan gum , cartilage , graphene , lubrication , articular cartilage , biomedical engineering , nanotechnology , composite material , osteoarthritis , medicine , chemistry , anatomy , alternative medicine , food science , pathology
In article number 2001434 by Leonardo Ricotti, Gina Lisignoli, Diego Trucco, and co‐workers, a bilayered hydrogel made of gellan gum and poly(ethylene glycol)diacrylate fills chondral defects of articular knee cartilage, mimicking the superficial and the deep zones in terms of mechanical and lubrication features. Graphene oxide dopant improves the superficial layer's lubrication. Such a nanocomposite hydrogel could be used as an injectable filler or a surgically implantable substitute in defects, showing no cytotoxicity, and guaranteeing suitable resistance to wear.