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Biomaterials Discovery: Discovery of a Novel Polymer for Xeno‐Free, Long‐Term Culture of Human Pluripotent Stem Cell Expansion (Adv. Healthcare Mater. 6/2021)
Author(s) -
Nasir Aishah,
Thorpe Jordan,
Burroughs Laurence,
Meurs Joris,
PijuanGalito Sara,
Irvine Derek J.,
Alexander Morgan R.,
Denning Chris
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202170019
Subject(s) - induced pluripotent stem cell , acrylate , polymer , materials science , stem cell , tissue engineering , nanotechnology , biomedical engineering , chemistry , microbiology and biotechnology , biology , embryonic stem cell , medicine , biochemistry , composite material , monomer , gene
In article number 2001448 by Morgan R. Alexander, Chris Denning, and co‐workers, a novel substrate for xeno‐free human pluripotent stem cell (hPSC) culture is discovered using a highthroughput multigenerational polymer microarray platform approach used to rapidly test over 600 polymers. This nanoscale phase separated blend of poly(tricyclodecane‐dimethanol diacrylate) and poly(butyl acrylate) (2:1 v/v) which supports hPSC expansion and differentiation after long‐term serial passage can be readily applied to common tissue culture plasticware.