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Magnetoelectric Nanoparticles Incorporated Biomimetic Matrix for Wireless Electrical Stimulation and Nerve Regeneration
Author(s) -
Zhang Yusheng,
Chen Suping,
Xiao Zhanwen,
Liu Xiaoyin,
Wu Chengheng,
Wu Kai,
Liu Amin,
Wei Dan,
Sun Jing,
Zhou Liangxue,
Fan Hongsong
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202100695
Subject(s) - neurogenesis , extracellular matrix , materials science , regeneration (biology) , self healing hydrogels , spinal cord injury , nanotechnology , in vivo , biomedical engineering , neuroscience , computer science , spinal cord , biology , microbiology and biotechnology , engineering , polymer chemistry
Abstract Electrical stimulation is regarded pivotal to promote repair of nerve injuries, however, failed to get extensive application in vivo due to the challenges in noninvasive electrical loading accompanying with construction of biomimetic cell niche. Herein, a new concept of magneto responsive electric 3D matrix for remote and wireless electrical stimulation is demonstrated. By the preparation of magnetoelectric core/shell structured Fe 3 O 4 @BaTiO 3 NPs‐loaded hyaluronan/collagen hydrogels, which recapitulate considerable magneto‐electricity and vital features of native neural extracellular matrix, the enhancement of neurogenesis both in cellular level and spinal cord injury in vivo with external pulsed magnetic field applied is proved. The findings pave the way for a novel class of remote controlling and delivering electricity through extracellular niches‐mimicked hydrogel network, arising prospects not only in neurogenesis but also in human–computer interaction with higher resolution.