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Quantitative Photothermal Characterization with Bioprinted 3D Complex Tissue Constructs for Early‐Stage Breast Cancer Therapy Using Gold Nanorods
Author(s) -
Nam KiHwan,
Jeong Chan Bae,
Kim HyeMi,
Ahn Minjun,
Ahn SungJun,
Hur Hwan,
Kim Dong Uk,
Jang Jinah,
Gwon HuiJeong,
Lim YounMook,
Cho DongWoo,
Lee KyeSung,
Bae Ji Yong,
Chang Ki Soo
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202100636
Subject(s) - photothermal therapy , materials science , nanorod , photothermal effect , biomedical engineering , nanotechnology , colloidal gold , characterization (materials science) , breast cancer , stage (stratigraphy) , nanoparticle , cancer , medicine , paleontology , biology
Plasmonic photothermal therapy (PPTT) using gold nanoparticles (AuNPs) has shown great potential for use in selective tumor treatment, because the AuNPs can generate destructive heat preferentially upon irradiation. However, PPTT using AuNPs has not been added to practice, owing to insufficient heating methods and tissue temperature measurement techniques, leading to unreliable and inaccurate treatments. Because the photothermal properties of AuNPs vary with laser power, particle optical density, and tissue depth, the accurate prediction of heat generation is indispensable for clinical treatment. In this report, bioprinted 3D complex tissue constructs comprising processed gel obtained from porcine skin and human decellularized adipose tissue are presented for characterization of the photothermal properties of gold nanorods (AuNRs) having an aspect ratio of 3.7 irradiated by a near‐infrared laser. Moreover, an analytical function is suggested for achieving PPTT that can cause thermal damage selectively on early‐stage human breast cancer by regulating the heat generation of the AuNRs in the tissue.