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Tumor Associated Macrophages and TAMs‐Based Anti‐Tumor Nanomedicines
Author(s) -
Cheng Yuxi,
Song Siyang,
Wu Peiyao,
Lyu Bochen,
Qin Mengmeng,
Sun Yanan,
Sun Aning,
Mu Limin,
Xu Fei,
Zhang Lu,
Wang Jiancheng,
Zhang Qiang
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202100590
Subject(s) - nanomedicine , cancer research , drug delivery , metastasis , tumor microenvironment , medicine , tumor cells , cancer , nanotechnology , materials science , nanoparticle
As an important part of tumor microenvironment, tumor associated macrophages (TAMs) play a vital role in the occurrence, development, invasion, and metastasis of many malignant tumors and can significantly promote the formation of tumor blood vessels and lymphatic vessels, hence TAMs are greatly associated with poor prognosis. The research on nanomedicine has achieved huge progress, and nano‐drugs have been widely utilized to treat various diseases through different mechanisms. Therefore, developing nano‐drugs that are based on TAMs‐associated anti‐tumor mechanisms to effectively suppress tumor growth is expected to be a promising research filed. This paper introduces relevant information about TAMs in terms of their origin, and their roles in tumor genesis, development and metastasis. Furthermore, TAMs‐related anti‐tumor nano‐drugs are summarized. Specifically, a wide range of nano‐drugs targeting at TAMs are introduced, and categorized according to their therapeutic mechanisms toward tumors. Additionally, various nano delivery platforms using TAMs as cell carriers which aim at inhibiting tumor growth are reviewed. These two parts elucidate that the exploration of nanomedicine is essential to the study on TAMs‐related anti‐tumor strategies. This review is also intended to provide novel ideas for in‐depth investigation on anti‐tumor molecular mechanisms and nano‐drug delivery systems based on TAMs.