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3D Printing of Strontium Silicate Microcylinder‐Containing Multicellular Biomaterial Inks for Vascularized Skin Regeneration
Author(s) -
Ma Jingge,
Qin Chen,
Wu Jinfu,
Zhang Hongjian,
Zhuang Hui,
Zhang Meng,
Zhang Zhaowenbin,
Ma Lingling,
Wang Xin,
Ma Bing,
Chang Jiang,
Wu Chengtie
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202100523
Subject(s) - angiogenesis , regeneration (biology) , biomaterial , in vivo , tissue engineering , biomedical engineering , wound healing , materials science , multicellular organism , neovascularization , microbiology and biotechnology , cell , chemistry , biology , medicine , surgery , cancer research , biochemistry
The reconstruction of dermal blood vessels is essential for skin regeneration process. However, the lack of vascular structure, insufficient angiogenesis induction, and ineffective graft‐host anastomosis of the existing skin substitutes are major bottle‐necks for permanent skin replacement in tissue engineering. In this study, the uniform strontium silicate (SS) microcylinders are successfully synthesized and integrated into the biomaterial ink to serve as stable cell‐induced factors for angiogenesis, and then a functional skin substitute based on a vascularization‐induced biomimetic multicellular system is prepared via a “cell‐writing” bioprinting technology. With an unprecedented combination of vascularized skin‐mimicking structure and vascularization‐induced function, the SS‐containing multicellular system exhibits outstanding angiogenic activity both in vitro and in vivo. As a result, the bioprinted skin substitutes significantly accelerate the healing of both acute and chronic wounds by promoting the graft‐host integration and vascularized skin regeneration in three animal models. Therefore, the study provides a referable strategy to fabricate biomimetic multicellular constructs with angiogenesis‐induced function for regeneration of vascularized complex and hierarchical tissues.