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Innovations in Biomaterial Design toward Successful RNA Interference Therapy for Cancer Treatment
Author(s) -
Ward Deidra M.,
Shodeinde Aaliyah B.,
Peppas Nicholas A.
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202100350
Subject(s) - rna interference , nanocarriers , oligonucleotide , cancer therapy , genetic enhancement , cancer , cancer treatment , computational biology , rna , biology , nanotechnology , drug delivery , gene , materials science , genetics
Gene regulation using RNA interference (RNAi) therapy has been developed as one of the frontiers in cancer treatment. The ability to tailor the expression of genes by delivering synthetic oligonucleotides to tumor cells has transformed the way scientists think about treating cancer. However, its clinical application has been limited due to the need to deliver synthetic RNAi oligonucleotides efficiently and effectively to target cells. Advances in nanotechnology and biomaterials have begun to address the limitations to RNAi therapeutic delivery, increasing the likelihood of RNAi therapeutics for cancer treatment in clinical settings. Herein, innovations in the design of nanocarriers for the delivery of oligonucleotides for successful RNAi therapy are discussed.