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Cationic Tricyclic AIEgens for Concomitant Bacterial Discrimination and Inhibition
Author(s) -
Wang Bingnan,
Wu Haozhong,
Hu Rong,
Liu Xiaolin,
Liu Zhiyang,
Wang Zhiming,
Qin Anjun,
Tang Ben Zhong
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202100136
Subject(s) - cationic polymerization , aggregation induced emission , tricyclic , fluorescence , chemistry , quenching (fluorescence) , combinatorial chemistry , staining , bacteria , biophysics , materials science , organic chemistry , biology , physics , quantum mechanics , genetics
Abstract New ionic compounds with aggregation‐induced emission (AIE) feature has been widely studied. These AIE‐based luminogens (AIEgens) not only effectively resolve aggregation‐caused quenching (ACQ) problems that are encountered for most of conventional fluorescent dyes, but also exhibit promising applications in biological imaging, potentially for a wide variety of diseases. However, such an AIE system needs to be further developed. In this work, a series of novel cationic AIEgens that are comprised of tricyclic 2‐aminopyridinium derivatives with seven‐membered rings are designed and synthesized via a simple, multicomponent reaction. Notably, these AIEgens exhibit the ability to specifically stain gram‐positive bacteria. Moreover, a specific AIEgen, BMTAP‐7, possesses highly efficient bacteriostatic ability for Staphylococcus aureus ( S. aureus ) in both liquid medium and solid agar plates, which have a minimum inhibitory concentration (MIC) between 4 and 8 µg mL −1 . Using live‐cell imaging and a wash‐free process, it is observed that hydrophilic AIEgens are localized to mitochondria, whereas lipophilic AIEgens display specific staining of lysosomes. These AIEgens with bacteriostatic activity hold great promise for distinguishing between bacterial types and inhibiting bacterial infections in situ.