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An Ultra‐Stable, Oxygen‐Supply Nanoprobe Emitting in Near‐Infrared‐II Window to Guide and Enhance Radiotherapy by Promoting Anti‐Tumor Immunity
Author(s) -
Wang Meng,
Li Hao,
Huang Biao,
Chen Song,
Cui Ran,
Sun ZhiJun,
Zhang Mingxi,
Sun Taolei
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202100090
Subject(s) - nanoprobe , tumor hypoxia , materials science , polyethylene glycol , radiation therapy , nanotechnology , cancer research , biophysics , nanoparticle , chemistry , medicine , biochemistry , biology
Currently, radiotherapy (RT) is the main method for cancer treatment. However, the hypoxic environment of solid tumors is likely to cause resistance or failure of RT. Moreover, high‐dose radiation may cause side effects to surrounding normal tissues. In this study, a new type of nanozyme is developed by doping Mn (II) ions into Ag 2 Se quantum dots (QDs) emitting in the second near‐infrared window (NIR‐II, 1000–1700 nm). Through the catalysis of Mn (II) ions, the nanozymes can trigger the rapid decomposition of H 2 O 2 and produce O 2 . Conjugated with tumor‐targeting arginine‐glycine‐aspartate (RGD) tripeptides and polyethylene glycol (PEG) molecules, the nanozymes are then constructed into in vivo nanoprobes for NIR‐II imaging‐guided RT of tumors. Owing to the radiosensitive activity of the element Ag, the nanoprobes can promote radiation energy deposition. The specific tumor‐targeting and NIR‐II emitting abilities of the nanoprobes facilitate the precise tumor localization, which enables precise RT with low side effects. Moreover, their ultra‐stability in the living body ensures that the nanoprobes continuously produce oxygen and relieve the hypoxia of tumors to enhance RT efficacy. Guided by real‐time and high‐clarity imaging, the nanoprobe‐mediated RT promotes anti‐tumor immunity, which significantly inhibits the growth of tumors or even cures them completely.