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Dual‐Cues Laden Scaffold Facilitates Neurovascular Regeneration and Motor Functional Recovery After Complete Spinal Cord Injury
Author(s) -
Liu Dingyang,
Shen He,
Shen Yeyu,
Long Ge,
He Xinghui,
Zhao Yannan,
Yang Zhiquan,
Dai Jianwu,
Li Xing
Publication year - 2021
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.202100089
Subject(s) - regeneration (biology) , spinal cord injury , scaffold , axon , lesion , neuroscience , glial scar , neurite , spinal cord , medicine , anatomy , biomedical engineering , biology , microbiology and biotechnology , pathology , in vitro , biochemistry
Complete transection spinal cord injury (SCI) severely disrupts the integrity of both neural circuits and the microvasculature system. Hence, fabricating a functional bio‐scaffold that could coordinate axonal regeneration and vascular reconstruction in the lesion area may emerge as a new paradigm for complete SCI repair. In this study, a photosensitive hydrogel scaffold loaded with collagen‐binding stromal cell‐derived factor‐1a and Taxol liposomes is capable of inducing migration of endothelial cells and promoting neurite outgrowth of neurons in vitro. In addition, when implanted into a rat T8 complete transection SCI model, the above dual‐cues laden scaffold exhibits a synergistic effect on facilitating axon and vessel regeneration in the lesion area within 10 days after injury. Moreover, long‐term therapeutic effects are also observed after dual‐cues laden scaffold implantation, including revascularization, descending and propriospinal axonal regeneration, fibrotic scar reduction, electrophysiological recovery, and motor function improvement. In summary, the dual‐cues laden scaffold has good clinical application potential for patients with severe SCI.